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Miranda, Michele and Botti, Dario:
Tyrosinase: a pleiotropic regulator by means of tyrosine level control and melanogenesis
Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti Serie 8 69 (1980), fasc. n.6, p. 450-457, (English)
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Viene presentato un modello nel quale la tirosinasi occupa un ruolo centrale, come possibile regolatore della catecolaminosintesi, dell'assemblaggio dei microtubuli, della sintesi di tiroxina, della glicolisi e del ciclo dei pentosi fosfati, mediante una auto modulazione basata sul livello di tirosina e sulla produzione di melanina. Sono discusse possibili applicazioni del modello a condizioni normali e patologiche, come la fenilchetonuria, il parkinsonismo, la proliferazione dei melanociti e la rigenerazione della pelle (in condizioni fisiologiche o dopo irradiazione U.V.). Sono anche discusse brevemente le implicazioni sistemiche del modello.
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