A morphological and histochemical study focused on synaptic receptors of Dugesia gonocephala s.l. (Platheminthes, Turbellaria, Tricladida) has been conducted in 90 specimens. Special concern was given to the synaptic function of a reference zone closest to the eyes. The motor pattern of Dugesia was investigated administering different drugs acting on dopaminergic systems either stimulating (l-dopa, apomorphine, piribedil), or blocking (haloperidol), or depleting monoamine containing neurons like reserpine. Our results seem to suggest that motor performances of Dugesia are under dopaminergic control with a striking similarity to the nigro-striatal pathway of high Vertebrates. This very simple living model of the dopaminergic system could be of special interest in detecting neurophysiological properties of dopaminergic functional systems of high Vertebrates.
Referenze Bibliografiche
ANDEN N. E., CORRODI H., FUXE K., HOKFELT B., HOKFELT T., RYDIN C. e SVENSSON T. (1970) - «Life Sci.», 9, 513.
ARIËNS KAPPERS C. U. (1929) - The evolution of the nervous system in Invertebrates, Vertebrates and Man. E. F. Bohn, Haarlem, Nederthlands.
BARBEAU A. (1961) - «Arch. Neurol.», 4, 97.
BARBEAU A. (1974) - Drugs affecting movement disorders, in: «Annual Review of Pharmacology». H.W. Elliot, R. Okan, R. George eds., «Ann. Rew. Inc.», Palo alto (U.S.A.), 14, 91.
BLASCHKO H. (1939) - «J. Physiol.», 96, 50.
BULLOCK T. H. e HORRIDGE G. A. (1965) - Structure and function in the nervous systems of Invertebrates. W. H. Freeman and Co., San Francisco-London, 1 e 2.
BURKARD W. P., GEY K. F. e PLETSCHER A. (1962) - «Experientia», 18, 411.
CARLSSON A. (1959) - «Pharmacol. Rev.», 11, 490.
CARLSSON A. (1965) - Drugs which block the storage of 5- HT and related amines, in: «Handbook of experimental pharmacology». O. Eichler, A. Forale eds., Springer-Verlag, N. Y., 529.
DAHL E., FALCK B., VON MECKLENBURG C., MYHRBERG H. e ROSENGREN E. (1966) - «Z. Zellforsch.», 71, 489.
DE BEAUCHAMP P. (1961) - Plathelminthes, in: «Traité de Zoologie». P. P. Grasse ed., Masson e C., Paris, IV/1, 70.
DE ROBERTIS E. (1959) - «Int. Rew. of Cytol.», 8, 61.
ECCLES J. C. (1964) - The physiology of synapses. Springer-Verlag, Berlin.
EHRINGER H. e HORNYKIEWICZ O. (1960) - «Klin. Wschr.», 38, 1236.
FALCK B., HILLARP N.-Ă., THIEME G. e TORP A. (1962) - «J. Histochem. Cytochem.», 10, 348.
FUXE K., CORRODI H., FARNEBO L. O., GOLDSTEIN M., HAMBERGER B. e UNGERSTEDT U. (1972) - On the neuropharmacology of ET-495, in: «Symp. Internat. Trivastal», Monastir.
FUXE K. e JONSSON G. (1973) - «J. Histochem. Cytochem.», 21, 293.
GOODMAN L. S. e GILMAN A. (1966) - The pharmacological basis of therapeutics. McMillian, N. Y.
GREMIGNI V. e DOMENICI L. (1974) - «Cell Tiss. Res.», 150, 271.
GRILLO M. A., JACOBS L. e COMROE J. H. Jr.- (1974) - «J. Comp. Neurol.», 153, 1.
HAY E. D. e COWARD S. J. (1975) - «J. Ultrastruct. Res.», 50, 1.
KOOPOWITZ H. e CHIEN P. (1974) - «Cell Tiss Res.», 155, 337.
LENTZ T. L. (1967) - «J. Morphol.», 121, 323.
LENTZ T. L. (1968) - Primitive nervous systems. Yale University Press, New Haven and London.
LIBET B. (1970) - «Fed. Proc.», 29, 1945.
MORITA M. e BEST J. B. (1966) - «J. Exp. Zool.», 161, 391.
PALLADINI G. e LAURO G. (1967) - «Boll. Zool.», 34, 154.
PALLADINI G., REITANO M. e VENTURINI G. (1973) - «Rend. Acc. Naz. Lincei», ser. VIII, 54, 474.
PALLADINI G., CONFORTI A., MEDOLAGO L., VENTURINI G. e REITANO M. (1974 a) - «Acta Neurologica», 29, 417.
PALLADINI G., VENTURINI G., ANGELERI S., AGNOLI A. e CONFORTI A. (1974 b) - «Atti della I Riunione Stato attuale delle conoscenze sulle malattie extrapiramidali», L'Aquila, 105.
PALLADINI G., PISTONE A. e ZELAZEK S. (1975) - «Rend. Acc. Naz. Lincei», ser. VIII, 58, 64.
PARKER G. H. (1919) - The elementary nervous system. Lippincott, Phil.
SHERRINGTON C. S. (1906) - The integrative action of the nervous system. Yale University Press, New Haven.
STEFANELLI A. (1974) - «Cultura e scuola», 51, 190.
STEFANELLI A. (1975) - «Accademia Lincei. Seminario sulla Evoluzione Biologica - Centro Linceo Interdisciplinare», 7, 239.
SWEENEY D. (1963) - «Science», 139, 1051.
WELSH J. H. (1946) - «Anat. Rec.», 94, 79.
WELSH J. H. e KING E. C. (1970) - «Comp. Biochem. Physiol.», 36, 683.
WELSH J. H. e MOORHEAD M. (1960) - «J. Neurochem.», 6, 146.
WELSH J. H. e WILLIAMS L. D. (1970) - «J. Comp. Neurol.», 138, 103.
WILSON S. A. K. (1914) - «Brain», 36, 427.
Con il contributo del Ministero per i Beni e le Attività Culturali