In the present investigations silica ("Aerosil") has been shown to produce adjuvant effect in guinea pigs, when injected subcutaneously at the same time and together with bovine gamma-globulin. Antibodies produced are primarily of the $\gamma 1$ type. The adjuvanticity of silica has been shown to be lower than that of Freund's cpmplete adjuvant and higher than that of aluminium gel. Adjuvant effect does not appear when silica and antigen are injected in different subcutaneous sites. It is suggested that the mechanism of the adjuvant effect of silica could be similar to that postulated for aluminium salts.
Referenze Bibliografiche
ALLISON A. C., HARINGTON J. S. e BIRBECK M., «J. Exp. Med.», 124, 141 (1966).
ARDOINO L. A., LO MONTE G., MANCINO D. e MATRACIA S., «Arch. de Vecchi», 35, 439 (1961).
BENACERRAF B., OVARY Z., BLOCH K. J. e FRANKLIN E. C., «J. Exp.Med.», 117, 937 (1963).
BLOCH K. J., KOURILSKY F.M., OVARY Z. e BENACERRAF B., «J. Exp.Med.», 117, 965 (1963).
CASELLI P., MANCINO D. e ARIENZO R., «Folia Medica», 50, 749 (1966).
GALLILY R. e FELDMAN M., «Immunology», 12, 197 (1967).
GHIRINGHELLI L. e PERNIS B., «Med. Lavoro», 49, 665 (1958).
GLENNY A. T., BUTTLE G. A. H. e STEVENS M. F., «J. Path. Bact.», 34, 267 (1931).
HOLT P. F. e BOWCOTT J. E. L., «Biochem. J.», 57, 471 (1954).
HOLT P. F. e WENT C. W., «Brit. J. Indust. Med.», 17, 25 (1960).
KESSEL R. W. I., MONACO L. e MARCHISIO M. A., «Brit. J. Exp. Path.», 44, 351 (1963).
OAKLEY C. L., BATTY I. e WARRACK H. G., «J. Path. Bact.», 63, 33 (1951).
OVARY Z., in «Immunological Methods, C.I.O.M.S. Symposium», Ed. J. F. Ackroyd, p. 259, Blackwell Scientific Publications, Oxford, England, 1964.
OVARY Z., BENACERRAF B. e BLOCH K. J., «J. Exp. Med.», 117, 951 (1963).
PERNIS B. e PARONETTO F., «Proc. Soc. Exp. Biol. Med.», 110, 390 (1962).
SCHEIDEGGER J. J., «Int. Arch. Allergy Appl. Immunol.», 7, 103 (1955).
STAVITSKY A. B., «J. Immunol.», 72, 360 (1954).
STAVITSKY A. B. e ARQUILLA E. R., «Int. Arch. Allergy Appl. Immunol.», 13, 1 (1958).
SZABÓ ST., CSÖGÖR ST., LÁSZLÓ I. e ADORJÁN E., «Arch. Roum. Path. Exp. Microbiol.», 26, 519 (1967).
WHITE R. G., COONS A. H. e CONNOLLY J. M., «J. Exp. Med.», 102, 73 (1955).