2-Thienyl-phenyl-ketone was nitrated with nitric acid in acetic anhydride or in sulphuric acid. 4-Nitro-2-thienyl-phenyl-ketone, 5-nitro and 3-nitro isomers were formed. In Ac2O the isomer percentages, determined by G.L.C. and U.V. spectroscopy, were 51,8%, 45,8% and 2,4% respectively. In sulphuric acid the 4-nitro isomer percentage increased (65%), owing to the greater deactivating effect of the carbonyl group protonated on oxygen.
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Con il contributo del Ministero per i Beni e le Attività Culturali