Lactate dehydrogenase of the brain exhibits a significant, reversible drop of LDH1 in the intoxication by nitrofurantoin. The observed modification of the LDH pattern has been that occurring in the metabolic shift of the tissue from respiration to glycolysis. The ratio between the pyridoxal and pyridoxamine form of aspartate aminotransferase has also shown a simultaneous shift toward the predominance of the “pyridoxal form” of the enzyme, as reported for immature and degenerating nervous tissues. The metabolic significance of the data is briefly discussed.
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Con il contributo del Ministero per i Beni e le Attività Culturali