Intraperitoneal administration of hydrocortisone to rats is followed by a decrease of the oxidation potential of plasma as calculated from the lactate/pyruvate ratio. The blood lactate is low despite the increase in lactate-pyruvate ratios. The data indicate that the increased reduction of NAD coenzymes may exert a primary effect in inhibiting carbohydrate breakdown and in increasing blood glucose and liver glycogen.
Referenze Bibliografiche
[1] LONG C. N. H., KATZIN B. e FRY E. G., «Endocrinology», 26, 309 (1940).
[2] CLARK I., «J. Biol. Chem.», 200, 69 (1953).
[3] LONG C. N. H., SMITH O. K. e FRY E. G., Metabolic Effects of Adrenal Hormones, 4 (Churchill, Lond.) 1960.
[4] ROSEN F., ROBERTS N. R. e NICHOL C. A., «J. Biol. Chem.», 234, 476 (1959).
[5] KVAM D. C. e PARKS R. E. Jr., «Am. J. Physiol.», 198, 21 (1960).
[6] MOKRASCH L. C., DAVIDSON W. D. e Mc GILVERY R. W., «J. Biol. Chem.», 222, 179 (1956).
[7] HILZ H., TARNOWSKI W. e AREND P., «Biochem. Biophys. Research Communs», 10, 492 (1963).
[8] GREENGARD D., WEBER G. e SINGHAL M., «Science», 141, 160 (1963).
[9] RAY P. D., FOSTER D. O. e LARDY H. A., «J. Biol. Chem.», 239, 3396 (1964).
[10] SEGAL H. L. e LOPEZ C. G., «Nature», 200, 143 (1963).
[11] FIORENTINI A. e CAMONI E., «Boll. Soc. It. Biol. Sper.», in corso di stampa.
[12] HUGGET A. ST e G. NIXON D. A., «Biochem. J.», 66, 12 P. (1957).
[13] HOHORST H. J., KREUTZ F. H. e BÜCHER T., «Biochem. Z.», 332, 18 (1959).
[14] WADE R. e JONES H. W. Jr., «J. Biol. Chem.», 220, 553 (1956).
[15]
FIORENTINI A., «
Rend. Acc. Naz. Lincei», (in corso di stampa). |
fulltext bdim[16] HUCKABEE W. E., «Am. J. Physiol.», 196, 253 (1959).
Con il contributo del Ministero per i Beni e le Attività Culturali