The formation of lactic acid from carbohydrate sources in the presence of oxygen (that is aerobic glycolysis) by normal rat tissues incubated in homologous lymphis not depressed as compared to that of the same tissues incubated either in homologous serum or a saline solution. Therefore, the present results are at variance with those of Warburg et alii [2] according to which normal tissues incubated in body fluids do not glycolyse aerobically. On the contrary, these data further support the generally held opinion that: 1) aerobic production of lactic acid by many normal tissues is not an artifact dependent on experimental variables but a true biological property of their own, and that: 2) the correlation between aerobic glycolysis and malignancy is not universal.
Referenze Bibliografiche
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[2] O. WARBURG, K. GAWEHN e A. W. GEISSLER, Weiterentwicklung der zellphysiologischen methoden, p. 496, Thieme, Stuttgart (1962).
[3] O. WARBURG, A. W. GEISSLER e S. LORENZ, Ibidem, p. 578.
[4] R. SCHOLZ, H. SCHMUTZ, TH. BÜCHER e J. O. LAMPEN, «Biochim. Z.», 331, 71 (1959).
[5] H. A. KREBS e K. HENSELEIT, «Z. Physiol. Chem.», 210, 33 (1932).
[6] J. L. BOLLMAN, J. C. CAIN e J. H. GRINDLAY, «J. Lab. din. Med.», 33, 1349 (1948).
[7] Cortesemente fornito dalla ETHICON, Inc., Somerville, N. J., U.S.A.
[8] J. L. BOLLMAN, «J. Lab. din. Med.», 33, 1348 (1948).
[9] J. L. GOWANS, «Brit. J. exp. Path.», 38, 67 (1957).
[10] A. C. AISENBERG, The glycolysis and respiration of Tumours, Academic Press, New York (1961).
[11] G. F. MITCHELL e J. F. A. P. MILLER, comunicazione personale (1967).
Con il contributo del Ministero per i Beni e le Attività Culturali